Selenium deficiency is still a global problem in livestock husbandry, and this micronutrient is commonly supplemented in ruminants around the world, especially during the neonatal period. The aim of this study was to assess the influence of selenium and vitamin E supplementation in young goats in neonatal period on the activity of the process of thrombopoiesis based on cytological evaluation of bone marrow smears. Twelve clinically healthy goats at the age of 2 days divided into two equal groups (n=6) participated in the study. Only animals from the experimental group received a single dose of Se and vitamin E on the second day of life. Bone marrow was collected three times (2nd day of life and after 15 and 25 days), stained with the MGG method, and subjected to cytological evaluation. Peripheral blood smears were also analysed three times. The bone marrow cells in the group receiving the supplement absorbed dyes faster and more intensively than the same cells in the control animals. The numbers of megakaryoblasts and megakaryocytes were higher in goats from the experimental group than in the control group, which indicated the intensification of thrombopoiesis in animals supplemented with selenium and vitamin E. The results of the morphological tests clearly indicated an increase in the number of platelets and a higher platelet volume in experimental group. It can be concluded that selenium and vitamin E supplementation has a positive impact on the thrombopoiesis in caprine bone marrow.