Otrzymano: Listopad 22, 2018
Zaakceptowano: Maj 08, 2019
Opublikowano online: 2019-09-01
Medicine and veterinary
The aim of the study was to assess iron metabolism parameters in response to frequent blood donations in Polish blood donors, highlighting gender-related differences. The study comprised 170 whole blood donors (44 females and 126 males) in the age range of 19-60 years, admitted to the Regional Blood Transfusion Center in Bydgoszcz. The control group consisted of 36 age- and sex-matched non-donors. The peripheral blood cell count and iron status parameters, such as: serum iron, ferritin, total- and unsaturated binding capacities, erythopoeitin and transferrin saturation were assessed. There were no statistical differences in basic hematological parameters between regular blood donors and non-donors. Ferritin concentrations in male as well as in female blood donors were significantly lower than in male and female non-donors. Moreover, total- and unsaturated iron binding in capacites were significantly increased in male donors compared with male non-donors. The ferritin concentration in males donating blood once a year was significantly higher than observed in women donating blood once a year. Unsaturated iron binding capacity was significantly decreased in male compared with female donors (1 blood donation/year). No statistical differences in iron metabolism parameters were found between male and female blood donors who donated blood 2-3 times per year. High-frequency blood donors, both males and females, are particularly exposed to iron deficiency. Serum ferritin concentration in males donating blood 2-3 times a year was similar to ferritin levels observed in females. Inclusion of ferritin testing in pre-donation qualification of regular donors should be considered to detect subclinical iron deficiency.
Boinska J., Sury M., Zawacka D, Filipiak J., Żekanowska E. 2019. Iron metabolism parameters in regular blood donors – gender related analysis. J. Elem., 24(4): 1395 - 1407. DOI: 10.5601/jelem.2019.24.1.1767
iron, iron metabolism, blood donors, anemia