Nutritional status, morphological and biochemical blood parameters in HIV-positive adults from northern Poland
Wrzesień 04, 2017
Styczeń 14, 2018
Lebiedzińska A., Majewski
M., Waszkiewicz M., Maksymowicz-Jaroszuk
A., Bierzyńska N., Lemańska M., Jankowska M., Smiatacz T., Szefer P., Karczewski J.K.
Since the onset of the HIV/AIDS epidemic, nutrition has been considered an important factor in the course of infection. The study enrolled 150 HIV-positive adults (21–58 years) and 150 control group adults from Gdansk and Bialystok, within the same age, sex and education. Dietary intake was assessed together with hematological and biochemical parameters. HIV-positive adults had a 5–33% lower intake of 15 nutrients. The most significantly different from the control (P < 0.05) were vitamins B and folic acid, vitamin A, vitamin C, iron, zinc, and copper. When considering the percentage of the Estimated Average Requirement (% of the EAR), the most severe nutritional deficiencies were found for folic acid, vitamin D and calcium (<52% of EAR). When taking into account the level of total intake (diet plus supplements) a severe deficiency remained only for calcium and vitamin D, with 47–58% of the EAR. In contrast, a higher intake of 15 nutrients has been reported in HIV-positive adults as compared to the control group, with the most significant increase of the daily intake for vitamins B (B1, B3, B12, folic acid), vitamin A, vitamin C, vitamin D, vitamin E, sodium, iron, and copper (22–120%). The differences observed in the increased intake between the groups correlated with higher daily diet supplementation by HIV-positive participants (P < 0.041). Interestingly, the supply of vitamin D, vitamin B6 and vitamin E was increased in 41 immunocompromised participants (27.3%) with white blood cell (WBC) counts below 4.3 103 µL-1, by: 23.5%, 10.1% and 6.6% , respectively (P < 0.05). In contrast, the supply of folic acid (20.8%), iron (14.2%), vitamin B12 (12.4%), copper (8.1%) and vitamin C (7.1%) was significantly decreased (P < 0.05). Higher CD4+T cells count ≥ 400 cells µL-1 was observed in women compared to men (P < 0.05). The total cholesterol level was significantly decreased in WBC counts below 4.3 103 µL-1 (167.6±33.98 vs. 193.2±48.59 mg dL-1, P < 0.020) as compared to high WBC counts. Targeted nutritional intervention may improve the nutritional intake and biochemical status of HIV-positive adults.
Lebiedzińska A., Majewski M., Waszkiewicz M., Maksymowicz-Jaroszuk J., Grzeszczuk A., Bierzyńska N., Lemańska M., Jankowska M., Smiatacz T., Szefer P., Karczewski J.K. 2018. Nutritional status, morphological and biochemical blood parameters in HIV-positive adults from northern Poland. J. Elem., 23(3): 927-946. DOI: 10.5601/jelem.2017.22.4.1526
HIV, CD4+T cells, food frequency questionnaire, vitamins, minerals