The  increased  milk   yield  in dairy  cattle  has  made  it  increasingly difficult   to balance accurately the  feed ration.  This  results  in  energy  and  mineral   deficiencies  as  well  as various homeostasis  disorders  including  calcium  and magnesium  balance  disorders,  which in urn lead  to  metabolic  disorders.   In  our  study,   we  chose to  assess    the  therapeutic efficacy  of two most popular products of this  type i.e. Glucalvet (Vetoquinol Biowet)  and Antiparen-N (Vetoquinol Biowet). The study was conducted on 33 HF  cows dipslaying  symptoms of postparturient paresis  that  occurred  between  2  and  4  day  postpartum.   The  cows were divided into two groups: group A and group B,  which  were administered Glucalvet and Antiparen-N, respectively. Blood  samples  were  taken  twice  from  the  jugular   vein  of each  animal  - just before and  24  hours  after  drug  administration.  The  samples  were  used  to  determine  serum concentrations  of Ca,  Mg,  P,  Cl  and  glucose.  The  average  body temperature   in  both groups was  slightly  below  normal  and  statistically  significantly increased  24  hours  after the intravenous  infusion.   The same  tendency  was  observed  for  the  pulse  rate.   The magnesium levels  in  the  first   group  improved  significantly after  drug  administration but  its level was  still lower  than  the  physiological  range.  In  the  second group of animals, a  slight drop in the Mg level  after  the Antiparen-N administration. Levels  of Ca  and P  increased  in both group of animals after  the  treatment. The  average  chloride  concentration  was  similar for  both assays. The  serum  glucose concentration  increased  significantly in both groups  of animals after drug  administration. Summing  up,  the  study  presented  in  this  paper  indicates  that  Glucalvet and  Antiparen-N prove  to be useful  in  the  treatment   of post-parturient paresis  conditioned by Ca and Mg deficiency.