The  Premenstrual Syndrome  (PMS)   is  described  as  a  cyclical   disorder related  to  the hormonal  changes  during  a  menstrual cycle,  which  affects the  emotional  and  physical   health  of many  women during  their reproductive  period of life.  The  PMS  can  obviously  change the  quality  of life.  The  syndrome  is  characterized by a  complex group of symptoms,  such as depression,  irritability, mood swings,  anxiety, abdominal  discomfort. These signs  occur during the  luteal  phase  of a menstrual cycle  and  disappear after the  onset of menses. Some  studies  suggest  that  a  variety of nutrients  may play  an  important   role  in  the mood swings  which  occur  cyclically during the  course  of the  premenstrual  syndrome  and that  some can have  a beneficial  impact,  especially  on the estrous  phase  of a menstrual cycle. The aim  of the  paper  is  to  review  the  results   of some  studies  concerning  the role of bioelements  in  patients  with  the  PMS. Concentrations  of magnesium,   zinc,  selenium   and  manganese  are  the  highest  during menses  and  the  lowest  in  the  ovulatory  phase. Fluctuations of the magnesium  concentration  during  a  menstrual cycle  and  the involvement  of this  element  in  many  cellular  pathways and  neuromuscular activities obviously affect  the  incidence  or  intensity  of the  PMS   symptoms. However, we  lack  firm   evidence that  magnesium   supplementation   can  have  a positive  effect  on  alleviating  the  the  PMS-related  ailments. Some relationship between the PMS  and bone demineralization or depressed calcium concentration  in  blood has  been identified.   However, further  studies  are necessary   to examine  how  the  calcium   concentration  in  a  human  body can  decrease  the  intensity of the PMS  symptoms.