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Journal Title Abbrev.
J. Elem.
ISSN – 1644-2296
DOI: 10.5601

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Toxicity of salinomycin and narasin in turkeys

Issue: 3/2014

Recevied: Dec 18, 2013

Accepted: Jun 24, 2014

Published: September 1, 2014

Authors:

Brak danych

Categories: Medicine and veterinary, Review paper

DOI: 10.5601/jelem.2014.19.1.567

Abstract:

Coccidiosis continues to be one of the most serious diseases in poultry breeding, causing major economic losses in this industry. Many trials are conducted to prevent and control this disease. However, only a few medications are approved for use in the prevention and treatment of coccidiosis. Ionophore coccidiostats (e.g. salinomycin and narasin) act by altering the transmembrane movement of monovalent or divalent ions (Na+, K+, Ca2+, Mg2+, Rb+, Cs+), resulting in altered ionic gradients and disturbed physiological processes in coccidia. In broiler and turkey breeding, these agents are used for nearly the whole fattening period. Ionophore coccidiostats have a narrow safety margin. Their toxicity is probably due to a disturbed ion balance or to oxidative damage. Although ionophore coccidiostats are considered to be relatively safe for target animals, there are numerous reports of poisoning cases caused by these medications in birds. This paper summarizes the current state of knowledge on the toxicity of salinomycin and narasin in turkeys. It reviews the data concerning the symptoms, mortality rate and possible causes of poisoning with these agents. Moreover, the paper discusses the legal regulations regarding the use of these drugs in poultry.

Citation:

quote-mark
Markiewicz W., Barski D., Burmańczuk A., Tomaszewska E. 2014. Toxicity of salinomycin and narasin in turkeys. J. Elem., 19(3): 903-914, 10.5601/jelem.2014.19.1.567

Keywords:

ionophore coccidiostats, salinomycin, narasin, toxicity, turkeys

About issue:

19.3.2014
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