Evaluation of zinc and copper concentrations and the total antioxidant capacity of blood plasma in patients with malabsorption syndrome
Wrzesień 07, 2014
Maj 25, 2015
Kanikowska A., Włochal M., Mielcarz G., Grzymisławski M., Kucharski A.M.
Disturbance of the antioxidative-oxidative balance is a predisposing factor in the development of a variety of diseases. Microelements, including zinc and copper, are components of active enzyme regions participating in anti-oxidative systems. Patients with malabsorption syndrome may suffer from diseases related to the chronic deficiency of micro- and macroelements and vitamins, but also experience health problems due to an impaired antioxidative plasma defence, i.e. illnesses caused by oxidative stress. The aim of the study was to assess zinc and copper concentrations as well as the total antioxidant capacity of blood plasma in 33 patients hospitalized in the Department of Internal Medicine, Metabolic Diseases and Dietetics, presenting symptoms of intestinal malabsorption such as weight loss, abdominal pain and diarrhoea. Blood donors made up the control group. Statistically significantly lower concentrations of zinc and copper were found in the study group as compared to the control group for women and men together as well as for women and for men separately (p<0.05). A significantly lower FRAP (Ferric Reducing Ability of Plasma) value as a measure of blood plasma the total antioxidative capacity was found in the study group of men in comparison with men from the control group (p< 0.05). Patients showed deficiencies of the two microelements despite normal values of BMI (Body Mass Index) and laboratory parameters such as haemoglobin, protein, albumin and iron concentrations. Regardless of the nutritional state assessment, patients with malabsorption syndrome should receive adequate supplementation of vitamins and microelements.
Kanikowska A., Włochal M., Mielcarz G., Grzymisławski M., Kucharski A.M. 2015. Evaluation of zinc and copper concentrations and the total antioxidant capacity of blood plasma in patients with malabsorption syndrome. J. Elem., 20(4): 873 - 885, DOI: 10.5601/jelem.2015.20.1.737
microelements, antioxidative plasma defense, impaired intestinal absorption