Influence of the selected antibiotic on absorption process of Mg2+ ions from solid dispersions containing glutamate magnesium salts
Marcoin W., Szulc-Musioł B.
Numerous papers concerning the research on the role of magnesium in the organism and the effects of its deficiency indicate that there are many causes and mechanisms leading to a negative balance of this macroelement. One of the causes of magnedium deficiency in systems may be its absorption from the digestive track resulting in taking compounds binding magnesium ions or using drugs destructive for saprophyte flora. The results of the experiments on the influence of β- lactam of penicillin G on the process of Mg2+ions absorption through intestinal membrane in vitro from solid dispersions containing phosphatidylcholine (PC 45) and the salts of magnesium glutamate and its derivatives from glycine and arginine ligands are presented in this paper. In order to make solid dispersions containing glutamate magnesium salts an auxiliary substances- polyvinylopyrrolidone (PVP) and phosphatidylcholine (PC 45)- were used. For the solid dispersions obtained by Hansch method partition coefficient in the system n - octanol/phosphate buffer was determined. And log P was calculated for the examined dispersions. Research on the degree of absorption of Mg2+ ions from solid dispersions, which was the subject of the experiment, was made in vitro using the model of a rat's intestine (ileum). Evaluation of penicillin G influence on the degree of absorption of Mg2+ ions from solid dispersions containing magnesium salts were carried out by the above- mentioned method. The results of the experiments indicate that additional ligand (glycine, arginine) in the structure of magnesium glutamate particle significantly influences the change in the value of the parameter of kinetic absorption of Mg2+ ions from solid dispersions containing magnesium salts. Introducing additional ligand influences the quicker rate of diffusion of the examined salts through intestine. It has been found that penicillin G hinders the degree of Mg2+ ions absorption of the examined solid dispersions in small intestine.
Marcoin W., Szulc-Musioł B. 2015. Influence of the selected antibiotic on absorption process of Mg2+ ions from solid dispersions containing glutamate magnesium salts J. Elem., 20(1): 177 - 184, DOI: 10.5601/jelem.2013.18.4.520
magnesium glutamate, amino acids: glycine, arginine, penicillin G, solid dispersion, log P, absorption