Effect of lithium treatment on the content of lithium, copper, calcium, magnesium, zinc and iron in the hair of patients with bipolar disorder


Wydanie: 4 / 2021

Otrzymano: Lipiec 24, 2021

Zaakceptowano: Wrzesień 16, 2021

Opublikowano online: 2021-10-01

Autorzy:

  • Kabzińska-Milewska K., Czajeczny D., Wójciak R.W.

Kategorie: Medicine and veterinary

DOI: 10.5601/jelem.2021.26.3.2172

Abstrakt:

The homeostasis of elements is essential for a healthy nervous system, which is crucial for patients with bipolar disorder. Abnormalities related to the supply, absorption, intracellular and extracellular concentrations of micronutrients are considered as factors in the pathogenesis of affective disorders. Lithium carbonate treatment influences levels of elements. The paper presents a study on the influence of lithium carbonate treatment on the content of selected elements (lithium, copper, iron, zinc, magnesium and calcium) in hair sample from bipolar patients. The study group consisted of 57 patients with the diagnosis of bipolar affective disorder. Each patient was in the remission phase. Two groups were distinguished according to the treatment – with or without lithium carbonate. The levels of lithium, copper, iron, zinc, magnesium and calcium were measured based on an analysis of hair samples. Patients taking lithium carbonate are characterized by a higher level of lithium (p<0.01), zinc (p<0.05) and magnesium (p<0.05), and lower iron content (p<0.05) in a hair sample. Significant differences were found for magnesium distribution (p<0.01) in the group not treated with lithium. In this group, moderate dependence occurred between magnesium and lithium (r=0.517, p=0.034), magnesium and calcium (r=0.564, p=0.018), magnesium and iron (r=0.510, p=0.037), and iron and lithium (r=0.532, p=0.028). The study shows that BD is associated with specific abnormalities in the level of trace elements in the human body. The balance of elements can be affected by medications. The study shows that lithium carbonate can affect the concentrations of elements.

Cytacja:

Kabzińska-Milewska K., Czajeczny D., Wójciak R.W. 2021. Effect of lithium treatment on the content of lithium, copper, calcium, magnesium, zinc and iron in the hair of patients with bipolar disorder. J. Elem., 26(4): 791 - 805. DOI:  10.5601/jelem.2021.26.3.2172

Słowa kluczowe:

Hair Analysis, Li, Mg, Ca, Cu, Fe, Zn

O wydaniu:

26.4.2021


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