Evaluation of the influence of a β-lactam antibiotic on the absorption process of Mg2+ ions from solid dispersions containing nicotinate magnesium salts
Czerwiec 03, 2019
Październik 11, 2019
Marcoin W., Szulc-Musioł B.
Magnesium belongs to the group of bioelements indispensable for the proper functioning of a human body. Many years of studies on the role of this element in the living system have revelaed its exact function in numerous, essential processes and metabolic transformation. According to previous studies, associations of magnesium with organic ligands enhance the absorption of magnesium ions. Interesting directions in the research are those that explain the problems of the loss of magnesium and interactions with other drugs.The subject of the study was to investigate the interaction between administered drugs and an antibiotic. This work is a continuation of the research into the influence of a β-lactam antibiotic on the absorption of Mg2+ ions from magnesium salts modified by such amino acids as glycine or arginine. The aim of the study was to evaluate the effect of penicillin G on the degree of the absorption of Mg2+ ions from nicotinate magnesium salts and its derivatives with glycine or arginine as well as from solid dispersions containing these salts. The process of the absorption of Mg2+ ions was examined in vitro on a model of the rat’s small intestine. The results showed that an additional ligand (glycine or arginine) in the structure of nicotinate magnesium significantly decreased values of the kinetic parameters measuring absorption of Mg2+ ions from solid dispersions containing magnesium salts. The addition of a phosphatidylcholine carrier (PC45) to solid dispersions containing nicotine magnesium salts has significantly decreased the rate of absorption of Mg2+ ions from these formulations. Moreover, the results of the experiments indicate that penicillin G inhibits the process of Mg2+ ion absorption from the examined solid dispersions in the small intestine.
Marcoin W., Szulc-Musioł B. 2020. The evaluation of the influence of β-lactam antibiotic on the absorption process of Mg2+ ions from solid dispersions containing nicotinate magnesium salts. J. Elem., 25(1): 169 - 179. DOI: 10.5601/jelem.2019.24.2.1832
nicotinate magnesium salts, glycine, arginine, penicillin G, solid dispersion, absorption