Analysis of serum copper and zinc concentration among excess body mass persons due to their age
Wydanie: 1 / 2011
Kategorie: Medicine and veterinary
Metabolic alterations in physiological aging may depend on oxidative-antioxidative balance and biomineral status. The aim was to analyze concentrations of serum copper (Cu) and zinc (Zn) among excess body mass persons due to their age. Material: 72 healthy Caucasians, divided into 3 groups: AGE1, AGE2, AGE3 (30-45, 46-60, 61-75 years old respectively), with body mass index (BMI) ł25 kg m–2 were qualified for oral glucose tolerance test (OGTT) and fasting (G0') and 2-hours (G120') glycemia were determined (enzymatically). Type 2 diabetes mellitus was excluded. Concentration of serum Cu and Zn (AAS), insulin (ELISA) and plasma lipids: total cholesterol, high density lipoproteins cholesterol, triacyloglyceroles (enzymatically) were measured in fasting samples. Low density lipoproteins cholesterol was obtained using Friedewald formula. Insulin Resistance ratios and Cu/Zn ratio were calculated. Results: No differences concerning BMI, waist, diastolic blood pressure, lipids and insulin concentrations and insulin resistance ratios were observed. Increasing G0’, G120' and systolic blood pressure from group 1 to 3 (p=0.01, p=0.01, p=0.04 respectively) were found. AGE2 group had the lowest Zn concentration 10.67±3.37 µmol dm–3, (p=0.002) and the highest Cu/Zn ratio 1.73±0.64 (p=0.0003). We calculated negative correlations Zn and SBP (R=-0.45, p=0.04), Zn and DBP (R=-0.46, p=0.04), Zn and G 120’ (R=-0.45, p=0.03) in the oldest group. Conclusions: Different zinc concentration while aging may occur, and may imply different metabolic usage of the biominerals, especially in obese patients otherwise healthy subjects.
Dzięgielewska S., Wysocka E., Cofta S., Torliński L. 2011. Analysis of serum copper and zinc concentration among excess body mass persons due to their age. J. Elem. 16(1): 21-30.
Słowa kluczowe:aging, trace elements, zinc, cooper